CVE-2026-17583 PUBLISHED

Thermo Fisher Applied Biosystems Genetic Analyzers Missing Support for Integrity Check

Assigner: icscert
Reserved: 27.07.2026 Published: 05.08.2026 Updated: 06.08.2026

The affected

Thermo Fisher Applied Biosystems Genetic Analyzers are vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.

CVSS Vector: CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H
CVSS Score: 8.4

Attack Vector	Local	Scope	Unchanged
Attack Complexity	Low	Confidentiality Impact	High
Privileges Required	None	Integrity Impact	High
User Interaction	None	Availability Impact	High

CVSS 3.1

CVSS Vector: CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:H/SC:N/SI:H/SA:N
CVSS Score: 8.3

Exploitability Metrics		Vulnerable System Impact Metrics		Subsequent System Impact Metrics
Attack Vector	Local	Confidentiality	None	Confidentiality	None
Attack Complexity	Low	Integrity	High	Integrity	High
Attack Requirements	None	Availability	High	Availability	None
Privileges Required	None
User Interaction	None

CVSS 4.0

Product Status

Vendor	Thermo Fisher
Product	Applied Biosystems 3500/3500xL Series Data Collection Software
Versions	Default: unaffected affected from 0 to 4.0.2 (incl.)

Vendor	Thermo Fisher
Product	Applied Biosystems 3730/3730xL Series Data Collection Software
Versions	Default: unaffected affected from 0 to 5.0.2 (incl.)

Vendor	Thermo Fisher
Product	Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software
Versions	Default: unaffected affected from 0 to 1.2.5 (incl.)

Vendor	Thermo Fisher
Product	Applied Biosystems SeqStudio Flex Series Instrument Software
Versions	Default: unaffected affected from 0 to 1.2.0 (incl.)

Vendor	Thermo Fisher
Product	Applied Biosystems GeneMapper ID-X Software
Versions	Default: unaffected affected from 0 to 1.7.3 (incl.)

Vendor	Thermo Fisher
Product	Applied Biosystems 3130 Series Data Collection Software
Versions	Default: unaffected affected from 0 to 4.1 (incl.)

Vendor	Thermo Fisher
Product	ABI PRISM 3100/3100-Avant Data Collection Software
Versions	Default: unaffected affected from 0 to 2.0 (incl.)

Vendor	Thermo Fisher
Product	ABI PRISM 310 Data Collection Software
Versions	Default: unaffected affected from 0 to 3.1 (incl.)

Workarounds

Applied Biosystems 3130 Series Data Collection Software: Product is End of Life (EoL), no update provided ABI PRISM 3100/3100-Avant Data Collection Software: Product is End of Life (EoL), no update provided ABI PRISM 310 Data Collection Software: Product is End of Life (EoL), no update provided

For users who are unable to immediately implement all applicable security updates, Thermo Fisher Scientific recommends implementing the following interim mitigation measures until the applicable updates have been installed:

Maintain a secure chain of custody for files generated by the HID instrumentation throughout the analysis workflow.
Store generated files on encrypted, password-protected storage media (for example, encrypted USB drives or encrypted hard drives).
Restrict access to generated files to authorized personnel in accordance with your laboratory's access control policies.
Apply the principle of least privilege by limiting user permissions on systems operating the HID instrumentation or hosting associated data analysis and secondary analysis software.
Leverage firewall rules and network access control lists (NACLs) to restrict internet connectivity to only trusted sources.

For more information, refer to Thermo Fisher's security bulletin. https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf

Solutions

Thermo Fisher has developed security updates to address the vulnerability. The security updates implement the use of digital signatures on the instrument software that adds an extralayer of protection. Moving forward, this will help users verify that data files have not been modified.

Applied Biosystems 3500/3500xL Series Data Collection Software: Update to version 4.0.3 https://downloads.thermofisher.com/3500_DCS_v4.0.3_Patch/v4.0.3_Patch_Installer.exe

Applied Biosystems 3730/3730xL Series Data Collection Software: Update to version 5.0.3 https://downloads.thermofisher.com/3730xl_UDC_v5.0.3_Patch/3730xl_UDC_v5.0.3_Patch.exe

Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software: Update to version 1.2.6 https://downloads.thermofisher.com/SeqStudio/1.2.6/SeqStudio-1.2.6.abpkg

Applied Biosystems SeqStudio Flex Series Instrument Software: Update to version 1.2.1 https://downloads.thermofisher.com/SeqStudioFlex/1.2.1/SeqStudioFlex-1.2.1.abpkg

Applied Biosystems GeneMapper ID-X Software: Update to version 1.7.4 https://downloads.thermofisher.com/GeneMapperID-Xv1.7.4_Patch/GMIDX_v1.7.4_Patch.exe

Credits

Nathaniel Adams, Laura Gaydosh-Combs, and Kevin Dyer reported this vulnerability to CISA. finder

References

Problem Types

CWE-353 CWE